DNA Structure and Replication Worksheet
A Grade 10 science worksheet covering the fundamental structure of DNA and the process of DNA replication.
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Standards
Topics
DNA Structure and Replication
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Read each question carefully and answer to the best of your ability. Show all your work where applicable.
1. Which of the following best describes the structure of DNA?
A single-stranded helix
A double helix
A triple helix
A branched structure
2. The backbone of a DNA molecule is composed of:
Nitrogenous bases and sugars
Sugars and phosphate groups
Nitrogenous bases and phosphate groups
Amino acids
3. The four nitrogenous bases found in DNA are Adenine, Thymine, Cytosine, and .
4. During DNA replication, the enzyme unwinds the DNA double helix.
5. DNA replication is described as , meaning each new DNA molecule consists of one original strand and one newly synthesized strand.
6. Label the following diagram of DNA with 'Phosphate', 'Sugar', and 'Nitrogenous Base'.

7. Briefly explain the role of hydrogen bonds in maintaining the DNA structure.
8. Adenine pairs with Guanine in a DNA molecule.
True
False
9. DNA replication occurs during the M phase of the cell cycle.
True
False
Match the enzyme with its function in DNA replication.
10. DNA Polymerase
a. Joins DNA fragments
11. Helicase
b. Synthesizes new DNA strands
12. Ligase
c. Unwinds the DNA double helix
13. Describe the process of DNA replication, including the key enzymes involved and their roles. You may use labeled diagrams to support your answer.