Reconstitution Calculation Worksheet

Reconstitution Calculation Worksheet

Read each question carefully and perform the necessary reconstitution calculations. Show all your work and include appropriate units in your final answers. Round all answers to two decimal places unless otherwise specified.

1. A medication vial contains 500 mg of powder. The label indicates that it should be reconstituted with 2.5 mL of sterile water to achieve a concentration of 200 mg/mL. How much diluent should be added to the vial?

2. You have a powdered drug with a total mass of 1.5 grams. If you reconstitute it with 7.5 mL of solvent, what will be the final concentration of the solution in mg/mL?

3. Reconstitution is the process of adding a liquid (known as the  ) to a powdered medication to create a usable solution.

4. The final   of a reconstituted solution is typically expressed in units of mg/mL or g/L.

5. If a drug vial contains 2 grams of powder and you want to achieve a concentration of 250 mg/mL, you would need to add   mL of diluent.

6. A physician orders 100 mg of a drug. The reconstituted solution has a concentration of 50 mg/mL. How many milliliters of the solution should be administered?

7. A 250 mg vial of a powdered antibiotic needs to be reconstituted to a concentration of 125 mg/mL. Calculate the volume of diluent required, assuming the powder itself occupies a negligible volume.

8. You have a 1 gram vial of a drug. The recommended concentration after reconstitution is 200 mg/mL. What is the total volume of the reconstituted solution and how much diluent should be added?

Consider the image of a beaker below when thinking about measuring diluent volumes.

9. When reconstituting a medication, the volume of the powdered drug itself always significantly contributes to the final volume of the solution.