Autosomal Recessive Inheritance Worksheet

Autosomal Recessive Inheritance

Read each question carefully and provide detailed answers. Use the Punnett square provided for relevant questions.

1. In autosomal recessive inheritance, an individual must inherit   copies of the mutated gene to express the disorder.

2. Individuals who carry one copy of the mutated gene but do not show symptoms are called  .

3. The probability of two carrier parents having an affected child is  .

1. Which of the following is a characteristic of autosomal recessive inheritance?

2. If two parents are heterozygous carriers (Aa) for an autosomal recessive disorder, what is the probability that their child will be a carrier?

Consider a hypothetical autosomal recessive disorder where 'A' represents the dominant allele (normal) and 'a' represents the recessive allele (affected). A couple, both carriers (Aa), are planning to have children.

1. Complete the Punnett square above for this cross.

2. What is the genotypic ratio of their offspring?

3. What is the phenotypic ratio of their offspring?

1. If a child has an autosomal recessive disorder, at least one of their parents must also have the disorder.

2. Autosomal recessive disorders typically skip generations in a pedigree.

Cystic Fibrosis (CF) is an autosomal recessive disorder. A couple has a child with CF. Neither parent has CF. Explain how this is possible, using appropriate genetic terminology.